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Recombinant Human FGF-21 重組人成纖維細胞生長因子21

品牌：翌圣生物
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翌圣生物科技(上海)股份有限公司更新時間：2024-12-24 09:03:45

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同類產(chǎn)品成纖維細胞生長因子(24件)

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詳細介紹

Fibroblast growth factor-21 (FGF-21) belongs to the large FGF family which is encoded by the FGF-21 gene. Mature human FGF-21 shows 81% aa identity to mouse FGF-21, and is known to be active on mouse cells. The c-DNA for FGF-21 predicts a 209 aa polypeptide that contains a 28 aa signal sequence and a 181 aa mature region. FGF21 is a metabolic regulator that provides efficient and durable glycemic and lipid control in various animal models. And the FGF21 is a liver-derived endocrine factor that stimulates glucose uptake in adipocytes. Pharmacologic studies show that FGF21 has broad metabolic actions in obese rodents and primates that include enhancing insulin sensitivity, decreasing triglyceride concentrations, and causing weight loss.

Product Properties

Synonyms	FGF21, FGF-21, fibroblast growth factor 21
Accession	Q9NSA1
GeneID	26291
Source	E.coli-derived human FGF-21 protein, His29-Ser209.
Molecular Weight	Approximately 19.4 kDa.
AA Sequence	HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA S
Tag	None
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	>96% by SDS-PAGE and HPLC analyses.
Biological Activity	The ED₅₀ as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 μg/ml, corresponding to a specific activity of > 2.0 × 10³ IU/mg in the presence of 5 µg/ml of recombinant mouse Klotho-β and 10 μg/ml of heparin. Fully biologically active when compared to standard.
Endotoxin	< 1.0 EU per 1μg of the protein by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.