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Recombinant Human CEACAM-8/CD66b (His Tag)

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翌圣生物科技(上海)股份有限公司更新時間：2024-12-24 09:03:45

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詳細介紹

Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM-8), also known as CGM6 and CD66b, is an approximately 95 kDa member of the human carcinoembryonic antigen (CEA) family that plays a role in cell adhesion, cell migration and pathogen binding. CEACAM-8 is anchored to cells by a glycophosphatidylinositol (GPI) motif and is expressed exclusively on granulocytes. Human CEACAM-8 is composed of a 34 amino acid (aa) signal peptide, a 29 aa propeptide segment which is removed in the mature form, and a 286 aa CEACAM-8 region containing one V-type and two C2-type Ig-like domains. A homologue for CEACAM-8 has not been identified in the mice or rats. Activation enhances surface expression of CEACAM-8 and is an activation marker in human neutrophils and eosinophils. Engagement of CEACAM-8 by mAb or galectin-3 activated a Src family kinase (lyn), and induced cellular adhesion, superoxide production, and degranulation of eosinophils. CEACAM-8 can form both homotypic, and heterotypic bonds with CEACAM-6 through interaction of the V-type Ig-like domains. Cross-linking of neutrophil CEACAM-8 augments cytokine secretion and beta2 integrin-mediated adhesion.

產品性質

別名	CD66b; CEACAM8; CGM6; CD67; NCA-95
Uniprot No.	P31997.2
表達區間及表達系統	Recombinant Human CEACAM-8/CD66b Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Gln35-Ser319.
分子量	Approximately 32.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
外觀	Sterile Filtered White lyophilized (freeze-dried) powder.
純度	> 95% as determined by SDS-PAGE and HPLC.
活性	SPR Data：Human CEACAM-8, His Tag immobilized on CM5 Chip can bind Human CEACAM-6, His Tag with an affinity constant of 4.59 μM as determined in SPR assay (Biacore T200).
內毒素	< 1.0 EU per 1μg of the protein by the LAL method.
制劑	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
復溶	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.